Fertility outcomes in women after controlled ovarian stimulation with gonadotropin releasing hormone agonist long protocol: fresh versus frozen embryo transfer

Abstract Background Along with progress in embryo cryopreservation, especially the vitrification, freeze all strategy has become more acceptable than ever. Some studies have found comparable or higher live birth rate frozen transfer (FET) fresh transfer(ET)in gonadotropin releasing hormone antagonist (GnRH-ant) protocol. However from our literature research, there been no reports about comparison between ET and FET agonist (GnRH-a) long The aim of this study is to retrospectively investigate whether patients benefit GnRH-a protocol using real-world data. Methods This a retrospective cohort study, which women undergoing at Chongqing Reproductive Genetics Institute January 2016 December 2018 were evaluated. primary outcome was rate. secondary outcomes implantation rate, clinical pregnancy loss ectopic Results A total 7,814 met inclusion criteria, implementing 5,216 cycles 2,598 cycles, respectively. demographic characteristics significantly different groups, except BMI. After controlling for broad range potential confounders including age, infertility duration, BMI, AMH, number oocytes retrieved available embryos, multivariate logistic regression analysis demonstrated that significant difference two groups (all P > 0.05). However, group ( < 0.001 = 0.012, respectively). Conclusions Under protocol, compared FET, associated infertile underwent vitro fertilization (IVF). should be individualized made caution